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EPO
Erythropoietin (EPO) is a glycoprotein cytokine and the principal endogenous regulator of erythropoiesis — the physiological process by which erythroid progenitor cells in the bone marrow are stimulated to differentiate and mature into circulating red blood cells. In structural terms, mature human EPO consists of 165 amino acids (following cleavage of the 27-amino acid N-terminal signal peptide from the 193-amino acid precursor) and is heavily glycosylated, with carbohydrate chains accounting for approximately 40% of its molecular weight.
In laboratory and pre-clinical research settings, recombinant human EPO (rhEPO) is studied across multiple biological systems owing to its dual receptor engagement profile and its role as both a haematopoietic growth factor and a pleiotropic tissue-protective cytokine. Its standardised IU-based dosing makes it well suited for reproducible, quantitative in vitro assays and dose-response studies.
When EPO binds to the homodimeric EPOR on erythroid progenitor cells, it initiates receptor dimerisation and activation of JAK2 kinase, which phosphorylates STAT5. Activated STAT5 translocates to the nucleus to drive transcription of genes promoting cell survival, proliferation, and differentiation along the erythroid lineage — inhibiting apoptosis of erythroid progenitors through upregulation of anti-apoptotic proteins including Bcl-xL. Parallel activation of PI3K/Akt and MAPK/ERK signalling cascades further supports progenitor cell survival and mitogenesis.
Via the heterodimeric EPOR/CD131 complex, EPO research has documented non-erythropoietic effects in brain, heart, and skeletal muscle tissue in pre-clinical models, including neuronal survival under hypoxic/ischaemic stress, attenuation of inflammatory mediators, promotion of angiogenesis, and support for mesenchymal stem cell osteogenic and endothelial transdifferentiation. The 4000 IU formulation supplied by Peptides Lab UK allows researchers to prepare a wide range of research concentrations for standardised pathway and receptor studies.
- Research-grade peptide for laboratory and scientific use
- Produced to the highest purity and stability standards
- Lyophilized (freeze-dried) for optimal preservation
- Available in multiple quantities to support diverse research needs
We provide PEPTIDES of the highest purity and quality to ensure accuracy and reliability in scientific research.
Each product undergoes rigorous testing and quality control to meet the highest industry standards.
Quality & Formulation
Manufactured under strict quality control standards, the products are supplied in lyophilized powder form, ensuring:
✔ Enhanced stability during storage
✔ Consistent purity across batches
✔ Reliable reproducibility for laboratory research
By purchasing from Begin-Peptides, you agree to the following:
Research Use Only – All products are strictly for research purposes and are not intended for human, therapeutic, diagnostic or clinical use.
Not Medical Products – Our products are not medical items and must not be marketed, sold, or used as such.
